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18, 21 Difluoro 2 2S 2 methyl 4 prop 2 enoyl piperazin 1 yl 6 propan 2 yl 10, 11, 13, 14 tetrahydro 4H 1, 19 ethenopyrido 3, 4 e pyrimido 6, 1 c 9, 2, 4 benzoxadiazacyclotridecin 4 one; 17, 20 difluoro 2 2S 2 methyl 4 prop 2 enoyl piperazin 1 yl 6 propan 2 yl 10, 11 dihydro 1, 18 ethenopyrido 3, 4 e pyrimido 6, 1 c 9, 2, 4 benzoxadiazacyclododecin 4 13H one; 18, 21 Difluoro 2 2S 2 methyl 4 prop 2 enoyl piperazin 1 yl 6 propan 2 yl 10, 11, 12, 13 tetrahydro 1, 19 ethenopyrido 3, 4 e pyrimido 6, 1 c 2, 4, 10 benzotriazacyclotridecine 4, 14 dione; 17, 20 Difluoro 2 2S 2 methyl 4 prop 2 enoyl piperazin 1 yl 6 propan 2 yl 12, 13 dihydro 1, 18 ethenopyrido 3, 4 e pyrimido 6, 1 c 7, 2, 4 benzoxadiazacyclododecin 4 11H one; 5aSa, 17aRa 20 chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 14, 17 difluoro 6 propan 2 yl 11, 12 dihydro 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 5aSa, 17aRa 20 Chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 14, 17 difluoro 6 propan 2 yl 11, 12 di 2H hydro 11, 12 2H2 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 5aRa, 18aRa 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 12, 12, 18, 21 tetrafluoro 6 propan 2 yl 10, 11, 12, 13 tetrahydro 4H 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 5aRa, 18aRa 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 12, 12, 17, 18, 21 pentafluoro 6 propan 2 yl 10, 11, 12, 13 tetrahydro 4H 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 5aRa, 18aRa 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 12, 12, 15, 18, 21 pentafluoro 6 propan 2 yl 10, 11, 12, 13 tetrahydro 4H 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 5aRa, 18aRa 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 12, 12, 16, 18, 21 pentafluoro 6 propan 2 yl 10, 11, 12, 13 tetrahydro 4H 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 5aSa, 17aRa 20 chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 16, 17 difluoro 6 propan 2 yl 11, 12 di 2H hydro 11, 12 2H2 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 12, 12, 17, 18, 21 pentafluoro 6 propan 2 yl 10, 11, 12, 13 tetrahydro 4H 1, 19 ethanediylidene dipyrimido 4, 5 f 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 21 chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 12, 12, 18 trifluoro 6 propan 2 yl 12, 13 dihydro 4H, 11H 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 5, 8, 10 benzodioxadiazacyclotridecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 18, 21 difluoro 6 propan 2 yl 10, 11 dihydro 4 H, 13 H spiro cyclopropane 1, 12 14 oxa 3, 5, 7, 20 tetraaza 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 15, 18, 21 trifluoro 6 propan 2 yl 10, 11 dihydro 4 H, 13 H spiro cyclopropane 1, 12 14 oxa 3, 5, 7, 20 tetraaza 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 17, 18, 21 trifluoro 6 propan 2 yl 10, 11 dihydro 4 H, 13 H spiro cyclopropane 1, 12 14 oxa 3, 5, 7, 20 tetraaza 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 20 chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 17 fluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 Dimethyl 4 prop 2 enoyl piperazin 1 yl 16, 17, 20 trifluoro 6 propan 2 yl 11, 12 di 2H hydro 11, 12 2H2 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 12, 12, 17, 18, 21 pentafluoro 6 propan 2 yl 2 4 prop 2 enoyl piperazin 1 yl 10, 11, 12, 13 tetrahydro 4H 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 12, 12, 17, 18, 21 pentafluoro 2 3R 3 methyl 4 prop 2 enoyl piperazin 1 yl 6 propan 2 yl 10, 11, 12, 13 tetrahydro 4H 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 2 2S, 5R 2, 5 Dimethyl 4 prop 2 enoyl piperazin 1 yl 14, 17, 20 trifluoro 6 propan 2 yl 11, 12 di 2H hydro 11, 12 2H2 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 22 fluoro 6 propan 2 yl 10, 11, 12, 13 tetrahydro 4H 1, 20 ethanediylidene pyrido 4, 3 12, 13 pyrimido 1, 6 1, 2 1, 3, 7 triazacyclotridecino 5, 6, 7 hi indazol 4 one; 9 chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 17, 20 difluoro 6 propan 2 yl 11, 12 dihydro 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 20 fluoro 6 propan 2 yl 17 trifluoromethyl 11, 12 dihydro 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 20 chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 16, 17 difluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenodipyrimido 4, 5 e 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 17, 20 difluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 17 chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 20 fluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 14, 16, 17, 20 tetrafluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 16, 17, 20 trifluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 15, 18, 21 trifluoro 2 2S 2 methyl 4 prop 2 enoyl piperazin 1 yl 6 propan 2 yl 10, 11, 12, 13 tetrahydro 4H 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 15, 16, 17, 20 tetrafluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 17, 20 difluoro 12 methyl 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 20 chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 14, 16 difluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 17 chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 20 fluoro 6 propan 2 yl 11, 12 dihydro 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 15, 16, 20 trifluoro 6 propan 2 yl 11, 12 dihydro 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 18, 21 difluoro 2 2S 4 2 fluoroprop 2 enoyl 2 methylpiperazin 1 yl 6 propan 2 yl 10, 11, 12, 13 tetrahydro 4H 1, 19 ethenopyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 20 fluoro 6 propan 2 yl 16 trifluoromethyl 11, 12 dihydro 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 6 chloro 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 14, 17, 20 trifluoro 11, 12 dihydro 4H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 19, 22 difluoro 24 methyl 7 propan 2 yl 11, 12, 13, 14 tetrahydro 4H 1, 20 etheno 6, 10 metheno pyrimido 1, 6 k 1, 8, 11, 13 benzoxatriazacyclohexadecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 16, 17, 20 trifluoro 10 methyl 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 16, 17, 20 trifluoro 6 propan 2 yl 4 H, 10 H, 12 H spiro cyclopropane 1, 11 13 oxa 3, 5, 7, 19 tetraaza 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 14, 17, 20 trifluoro 6 propan 2 yl 11, 12 dihydro 4H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7 benzodioxazacyclododecin 4 one; 11S 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 14, 17, 20 trifluoro 11 methyl 6 propan 2 yl 11, 12 dihydro 4H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 4, 7, 9 benzodioxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 14, 17, 20 trifluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2S, 5R 2, 5 dimethyl 4 prop 2 enoyl piperazin 1 yl 16, 19 difluoro 6 propan 2 yl 10, 11 dihydro 4H 1, 17 ethenopyrido 4, 3 d pyrimido 1, 6 f 1, 6, 8 benzoxadiazacycloundecin 4 one; 12, 12, 17, 18, 21 pentafluoro 2 2S 2 methyl 4 prop 2 enoyl piperazin 1 yl 6 propan 2 yl 10, 11, 12, 13 tetrahydro 4H 1, 19 ethanediylidene pyrido 4, 3 f pyrimido 1, 6 h 1, 8, 10 benzoxadiazacyclotridecin 4 one; 2 2S 2 ethyl 4 prop 2 enoyl piperazin 1 yl 17, 20 difluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2 difluoromethyl 4 prop 2 enoyl piperazin 1 yl 17, 20 difluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2 benzyl 4 prop 2 enoyl piperazin 1 yl 17, 20 difluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 17, 20 difluoro 6 propan 2 yl 2 4 prop 2 enoyl 2 2, 2, 2 trifluoroethyl piperazin 1 yl 11, 12 dihydro 4H, 10H 1, 18 ethanediylidene pyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 2, 2 dimethyl 4 prop 2 enoyl piperazin 1 yl 17, 20 difluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 2 3S 3 ethyl 4 prop 2 enoyl piperazin 1 yl 17, 20 difluoro 6 propan 2 yl 11, 12 dihydro 4H, 10H 1, 18 ethenopyrido 4, 3 e pyrimido 1, 6 g 1, 7, 9 benzoxadiazacyclododecin 4 one; 18, 21 difluoro 6 propan 2 yl 2 1S, 4S 5 prop 2 enoyl 2, 5 diazabicyclo 2
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